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January 10, 2025
A new study entitled “Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults” was recently published in Journal of Physical Activity and Health. A summary and citation is included below.
ABSTRACT
Background: There are no studies examining the prospective joint association of device-based measures of sedentary time and physical activity (PA) with cancer mortality. We examined the joint associations of sedentary time and intensity-specific PA with cancer mortality in 72,458 adults from UK Biobank.
Methods: Participants wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days (with at least 1 weekend day). Cox regression was performed to estimate hazard ratios (HR) and 95% confidence intervals (CIs) for joint associations of sedentary time and intensity-specific PA (light [LPA], moderate [MPA], and vigorous PA [VPA]) with cancer mortality (reference group: high intensity-specific PA and low sedentary time) adjusted for confounders and mutually adjusted for other PA intensities.
Results: Associations between sedentary time and cancer mortality were stronger among participants with low PA, irrespective of the intensity. Compared with participants with lower sedentary time (<11 h/d) and high MPA (median of 49 min/d), HR were 1.27 (95% CI, 0.90–1.78) for high sedentary time and high MPA, 1.35 (95% CI, 1.03–1.77) for high sedentary time and medium MPA (49 min/d), and 1.49 (95% CI, 1.15–1.92) for high sedentary time and low MPA (13 min/d). HR for high sedentary time and low light PA (61 min/d) and high sedentary time and low vigorous PA (1 min/d) were 1.25 (95% CI, 1.02–1.59) and 1.57 (95% CI, 1.20–2.06), respectively.
Conclusions: Relatively large amounts of LPA and MPA and small amounts of VPA appeared to attenuate the association between sedentary time and cancer mortality.
CITATION
Rezende, L. F., Ahmadi, M., Ferrari, G., del Pozo Cruz, B., Lee, I., Friedenreich, C. M., & Stamatakis, E. (2025). Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults. Journal of Physical Activity and Health (published online ahead of print 2025). Retrieved Jan 17, 2025, from https://doi.org/10.1123/jpah.2024-0436
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